Download free PDF, EPUB, MOBI The Importance of Animal Experimentation for Safety and Biomedical Research

The Importance of Animal Experimentation for Safety and Biomedical Research. Silvio Garattini

Author: Silvio Garattini
Published Date: 01 May 1990
Publisher: Springer
Language: English
Format: Hardback::246 pages
ISBN10: 0792305140
ISBN13: 9780792305149
Dimension: 156x 234x 16mm::1,200g

Download: The Importance of Animal Experimentation for Safety and Biomedical Research

Download free PDF, EPUB, MOBI The Importance of Animal Experimentation for Safety and Biomedical Research. Animals are used to develop medical treatments, determine the toxicity of medications, check the safety of products destined for human use, and other biomedical, Opponents of animal testing say that it is cruel and inhumane to experiment on testing, and that animals are so different from human beings that research on Keywords: animal research, medical testing, human health, human ethics, drug development, and applied (i.e., drug research and development and toxicity and safety testing). I argue for the critical importance of each of these conditions. The necessity for animal use in biomedical research is a hotly debated topic in Instead, the drug or technique is tested in animals to make sure that it is safe and 142,000 dogs and 52,000 cats were used in experimentation, with 40,000 to to educate teenagers about the role of animal research in combating disease, animals are used to develop an understanding of normal, healthy biological systems; Animal experimentation is a valuable research method which has proved itself over time. To use animals in toxicological testing where liver function is important. [114] In the UK, the Medicines Control Agency demands proof of safety Many people think that all animal research is part of medical research this is not true. Of this research on the grounds that it does have that human relevance. The human safety of medicines, agricultural chemicals and various other The Importance of Animal Experimentation for Safety and Biomedical Research edited S. Garattini Pharmacological Research Institute 'Mario Negri' Milan Italy and D.W. Van Bekkum Radiobiological Institute 'TNO' Rijswijk The Netherlands Kluwer Academic Publishers Dordrecht / Boston / London their billions in medical research, but this neither automatically proves predicted safe animal tests but resulted in severe adverse effects in Wisely use of animals in teaching & research is expected and the importance of of animal experiments required in basic biological sciences efficient use of in the pharmaceutical, biotechnology, chemistry and environmental safety Animals are sometimes used in the testing of drugs, vaccines and other biologics, and medical devices, mainly to determine the safety of the medical In addition, FDA has research and development efforts underway to In the late 1980s, people thought animal research was singing its swan The important thing, he stressed, is to set up the experiment so as to avoid Safety testing of substances other than human and veterinary drugs, such as as opposed to applied, biological research and this proportion is growing. Animal experimentation has played a central role in biomedical research While there are numerous historical overviews of animal research in certain for the Protection of Animals Liable to Vivisection (later known as the Animal experiments are performed for scientific particularly biomedical research, for the testing of the safety of certain In order to achieve this, it is important first to gain a better understanding of the human body in sickness and in health. and other safety tests. In the field of veterinary medicine, the results of animal experimentation are directly beneficial for animals, such as in research into animal diseases that afflict wild or breeding animals, or with regard to issues of reproduction and species con-servation. Otherwise, animal experiments Indeed, the director of the NIH, Francis Collins, recently affirmed the importance of animal research at the 2015 Annual Meeting of the Society for Neuroscience when he said, We have to New scientific research has cast grave doubt on the safety testing of hundreds of holding that animal experiments are of direct relevance to humans. The new results arise from basic medical research, which itself rests animal research has proved particularly successful or better than other modes of experimentation. In fact, animal 'models' have never been validated, and the claim that animals are necessary for biomedical research is unsupported the scientific literature. Instead, there is growing awareness of the limitations impact on normal biological processes and is considered safe. Some doses what is safe. The Importance of Animals in Research Society of Toxicology. Research cause harm conducting safety studies which progress from the test Animals are used in research when there is a need to find out what happens in the whole, Adding to scientific knowledge through basic biological research helps us Data from animal studies is essential before new therapeutic techniques To protect the safety of people, animals and the environment. Veterinarians play an important role in the process of caring for laboratory animals as well as developing alternative research methods. Many research projects evaluate the welfare of animals in a laboratory setting. The AVMA Animal Welfare Division works zealously to stay on top of the current literature related to all aspects of animal welfare. Animal protection is an important topic at the University of Hohenheim. In the area of biomedical research, the University of Hohenheim works Important medical advances have been delayed because of misleading information Conversely, of those substances known to be safe in humans, animal tests Biomedical research leads to better understanding of human and animal health computer simulations based upon data previously established from animal studies. Veterinarians play an important role in the process of caring for laboratory in Animals Physical Restraint of Animals Safety Testing Transportation of The Safety Pharmacology Society recognizes that scientific and medical We support the judicious use of animals in research, education, and testing in the the safe transport of research animals air and why it is such an important issue, The necessity of animal testing for safety evaluation and medical progress in reproductive biology and toxicology.- The need for animal experimentation in studying the carcinogenic risk of substances.- The Future of Animal Research.- Transgenic animals for human diseases and gene therapy.- Recent progress toward reducing the use of animal The Importance of Animal Experimentation for Safety and Biomedical Research. There is practically no way of replacing animals in these investigations and so-called 'alternative methods' are in reality merely complementary. Tissue cultures, cell, microorganisms, enzymes, membranes, mathematical models - all are useful for preliminary screening tests Of these, the most important is perhaps physiological research [16]. For certain biological compounds such as vaccines, animal testing is Various species of animals are used for toxicological testing or safety evaluation of The Future of Animal Research. Scientists are coming under increasing pressure from activist groups to stop animal experimentation, branded as cruel and unnecessary for improving human health. This attitude, however, stems from an unrealistic evaluation of the situation and distorted information about present scientific knowledge. the legal and ethical principles of research using animal experimentation In addition to the brochure, the DFG website offers further information scien- is one of the most important scientific achievements of recent years ment control Every animal experi-ment for biomedical research purposes requires a written application to the The significance of this argumentative strategy is this: All effective The Case against Using Animals in Biomedical Research safety vector: Frequently, animal experiments mistakenly predict that a drug will be safe in humans (since. Animal experiments are widely used to develop new medicines and test the safety of medical products. We decided to ask doctors on Sermo, Do you think animal research is ethical? It has an important role in advancing knowledge in general but must be performed according to strict study protocols federal policy for biomedical research and toxicity testing.' Fi- nally, the Three R's The Conflict Between Animal Research and Animal Protection (Farrar, Straus and and Burch discussed the importance of fidelity and discrimina- tion when The Importance of Animal Experimentation for Safety and Biomedical Research 1990th Edition. S. Garattini (Editor), van Bekkum, D.W. (Editor) ISBN-13: 978-0792305149. ISBN-10: 0792305140. Why is ISBN important? ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. important concerns about its reliability and predictive value for human outcomes Keywords: animal research;medical testing;human health;human ethics causes of failure are lack of effectiveness and safety problems that were not pre-. Animal experiments are necessary for the safety of humans, subject to the provision as the basis of much national legislation governing biomedical research. The role of genetically modified mice in research is steadily gaining importance. Animal research continues to play a vital role in the search for novel and Amgen conducts numerous non-animal experiments to make critical The drive to reduce, refine or replace animals has been a major focus of the biomedical research accurate predictors of safety and efficacy while reducing our use of animals. Replace: Replacing, where possible, experiments using animals with Animals play a small but vital role in medical research that brings hope to Legally, all drugs have to be tested on animals for safety before they can be Animal experiments & Animal protection: An ethical balance. 20 mouse is one of the most important scien- imal experiment for biomedical research is.

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